Regenerative Medicine and Stem Cells

How stem cells could help solve the transplant problem and make breakthroughs in almost every disease

Currently, regenerative medicine through stem cells is a game-changing field that has great potential to change everything. Recent advances have unlocked new opportunities and approaches for the use of stem cells such as rejuvenation, replacement, and regeneration according to The Center for Regenerative Medicine. With stem cells, it is possible to grow organs and tissues specifically for the needed person, reducing the chance of transplant rejection. Moreover, since stem cells can be grown in cultures, the shortage problem currently associated with transplants could be fixed entirely with the use of growth factors. Stem cells can also treat neurodegenerative diseases like Parkinson’s and Alzheimer’s among others, which do not have a cure currently, by working as replacement cells or tissues.

stemcell

How Stem Cells Could Transform Medicine

Stem cells are unique because they are unspecialized, they can differentiate, and they can self-renew. Stem cells do not have a tissue-specific structure yet, and they can differentiate, meaning they can become a wide variety of specialized cells. Unlike muscle, blood, and nerve cells, stem cells can immortally make millions of more of themselves. There are three main types of stem cells that I will address: totipotent, pluripotent, and multipotent stem cells. Three days after fertilization, there is a clump of sixteen cells called the morula, which is made up of totipotent stem cells because they can become anything in the body, including the placenta. Soon after, the cells begin to differentiate more with the outer layer becoming the blastocyst while the inner cell mass continues to divide. The inner cell mass is made up of pluripotent stem cells, which can also be referred to as embryonic stem cells. These stem cells can become anything except for the placenta because the blastocyst itself is the pre-placental cells. After the egg’s implantation in the uterus, gastrulation begins, and the embryo separates into three distinct layers, which are the ectoderm, mesoderm, and endoderm. Stem cells in each of these layers are multipotent or adult stem cells because they are more restricted in the variety of mature cells they can become. Adult stem cells can also be harvested from the bone marrow of an adult as well. Researchers generally experiment more with embryonic and adult stem cells rather than totipotent stem cells because they are a little more mature and specialized. 

stem cell transplant

Autologous Stem Cell Transplant Procedure

While stem cells hold extreme potential, there are some reasonable ethical concerns that need to be addressed because they are currently holding back research and experimentation. Some believe that an embryo, at the blastocyst stage, is a living human being rather than a group of cells. They believe that life starts at conception rather than in the womb or at birth. Thus, those people believe that it is essentially “murder” when researchers destroy the embryo to extract the pluripotent stem cells. A counterargument to this takes a more utilitarian standpoint, arguing that it is worth the possible death of one to save maybe hundreds of others. I do not agree nor disagree with these arguments, but maybe one day scientists do have arguments that appease everyone.

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Where the Pluripotent Cells Are Harvested

Regenerative medicine is now on of the of priorities of researchers throughout the world because of how it could change the future of medicine. Diseases thought to be incurable before may very well be treatable within even the next decade as clinical trials come in and researchers experiment more and more. At the moment, there are almost 120,000 people waiting to receive an organ, and three people die every hour because they could not get an organ in time. Stem cells could solve many of these cases, making breakthroughs in every medical field, and there is a solid reason to trust that they will.

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Number of Transplants by Catagory by the United Network for Organ Sharing

 

References

“About Regenerative Medicine.” Mayo Clinic, 2017, mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/about-regenerative-medicine. Accessed 8 June 2017.

Autologous Stem Cell Transplant. 28 Feb. 2014. BioNews Texas, bionews-tx.com/news/2014/02/28/new-research-provides-insights-for-immune-system-development-after-autologous-stem-cell-transplant-for-multiple-sclerosis/. Accessed 8 June 2017.

CNN library. “Stem Cells Fast Facts.” CNN, 2 June 2017, cnn.com/2013/07/05/health/stem-cells-fast-facts/index.html. Accessed 8 June 2017.

“Data.” United Network for Organ Sharing, 2015, unos.org/data/. Accessed 8 June 2017.

Ernst, Liz. “What Are the Potential Uses of Human Stem Cells? What Obstacles Must Still Be Overcome before These Potential Uses Will Be Realized?” Global Stem Cells Group, 28 June 2016, stemcellsgroup.com/human-stem-cells/. Accessed 8 June 2017.

Potential Uses of Stem Cells. 2014. All Things Stem Cell, allthingsstemcell.com/glossary/. Accessed 8 June 2017.

“Stem Cell Therapy Ethics.” Biomedinvo4all, biomedinvo4all.com/en/research-themes/stem-cell-therapy/stem-cell-therapy-ethics. Accessed 8 June 2017.

Writes, Laura. “Ethical Problems of Human Embryonic Stem Cell Use in Scientific Research.” Soapboxie, 19 Dec. 2015, soapboxie.com/social-issues/Ethical-Problems-of-Human-Embryonic-Stem-Cell-use-in-Scientific-Research. Accessed 8 June 2017.

  1. rsinghdgntechnologiescom June 17, 2017 at 4:49 pm

    Very interesting.

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  2. […] via Regenerative Medicine and Stem Cells — Medical Blog […]

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